Transcription factors, translocations, and leukemia
نویسندگان
چکیده
منابع مشابه
REVIEW ARTICLE Transcription Factors, Translocations, and Leukemia
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متن کاملTranscription factors, normal myeloid development, and leukemia.
cells specifically? (5) How does a common progenitor cell T become one type (myeloid) rather than another? RANSCRIPTION FACTORS play a major role in differentiation in a number of cell types, including the Currently, models have been advanced proposing that hevarious hematopoietic lineages. In the hematopoietic sysmatopoietic lineage determination is driven extrinsically tem, stem cells undergo...
متن کاملMolecular pathways: transcription factories and chromosomal translocations.
The mammalian nucleus is a highly complex structure that carries out a diverse range of functions such as DNA replication, cell division, RNA processing, and nuclear export/import. Many of these activities occur at discrete subcompartments that intersect with specific regions of the genome. Over the past few decades, evidence has accumulated to suggest that RNA transcription also occurs in spec...
متن کاملMixed lineage leukemia translocations and a leukemia stem cell program.
Cancer stem cells (CSC) may provide the self-renewal capacity required to sustain a tumor. One possibility is that CSC arise from the stem cell counterparts in normal tissues. Alternatively, CSC may arise from more differentiated progenitor cells found in certain tissues. In support of this idea, we showed recently that mixed lineage leukemia fusion oncoproteins can convert committed hematopoie...
متن کاملDo transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?
Chromosomal translocations are a key early event in many leukemias. Translocations involving the mixed lin-eage leukemia (MLL) locus, for example, are observed in a high proportion of neonatal acute lymphoblastic leukemia (ALL), and in therapy-related secondary acute leukemia (t-AL). Therapy related leukemia arises following various combinations of chemo-and radio-therapy, used in the treatment...
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ژورنال
عنوان ژورنال: Blood
سال: 1992
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v80.12.2953.bloodjournal80122953